Epitalon research: studies, doses and safety

A peptide with telomerase effects in cells, but no proof that people live longer.

Also called: Epithalon, Epithalone, AEDG, Ala-Glu-Asp-Gly.

Khavinson bioregulator peptides · Synthetic pineal tetrapeptide studied in telomere and circadian models.

A small night-shift-worker study used a sublingual Epitalon spray twice daily for 20 days; it measured body-clock gene activity.

Four human reports cover about three participant groups. Two night-shift reports likely reuse participants; longer human life is unproven.

Key studies

  • Retinitis pigmentosa: local eye injections: An old controlled report suggests visual changes but lacks modern trial safeguards. (source)
  • Older adults: 10 mcg IM course: A tiny IM study changed melatonin levels without showing better sleep or longer life. (source)
  • Night-shift workers: sublingual spray: A small biomarker trial does not establish insomnia treatment. (source)
  • Night-shift workers: companion gene report: A related report shows gene-expression changes after sublingual exposure. (source)
  • Telomerase in human fibroblasts: The central telomerase claim began as a cell-culture finding. (source)
  • Cultured cells beyond division limit: A culture result cannot establish human longevity. (source)

Related to Epitalon

Sources

Sources checked: 2026-10-18.

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