What does Thymosin beta-4 do? Benefits and evidence

A peptide studied for eye conditions and skin wounds; tendon-repair injections lack controlled human evidence.

Also called: Tβ4, TB4, TB-4, Timbetasin, Timbetasin acetate, RGN-259, RGN-137, RGN-352, NL005, a recombinant Tβ4-related product.

Healing and repair peptides · Full-length actin-binding peptide; related recombinant trial formulations.

Thymosin beta-4 is a natural 43-amino-acid peptide studied as sterile eye drops, skin gels and injections into a vein. No approved dose or controlled human evidence supports tendon-repair injections. Large dry-eye trials and overall ulcer results showed little benefit. One recombinant product contains 44 amino acids. It differs from the seven-amino-acid TB-500 fragment.

  • In a small uncontrolled study, eye drops with it improved some slow-healing sores on the surface of the eye. (Studied in a trial)
  • In a small randomized study, a scalp gel with it helped scalp dermatitis. (Studied in a trial)
  • People report less pain and easier rehab after shoulder surgery, though surgery and age may explain some of it. (Reported by users)

Uses in the sources

  • RGN-259 eye drops were studied for dry eye and neurotrophic corneal defects. Primary results were mixed or negative. (Studied in a trial) (source)
  • Skin gels were studied for chronic ulcers, fragile-skin wounds and scalp dermatitis. These findings do not establish injected recovery dosing. (Studied in a trial) (source)
  • IV products were studied for safety and after heart attacks. The published cardiac trial did not show an overall infarct-size benefit. (Studied in a trial) (source)
  • Community users inject products called TB4 for injury recovery. Reliable controlled human tendon-repair evidence is missing. (Reported by users) (source)

Related to Thymosin beta-4

Sources

Sources checked: 2026-10-18.

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