How Thymosin beta-4 works

A peptide studied for eye conditions and skin wounds; tendon-repair injections lack controlled human evidence.

Also called: Tβ4, TB4, TB-4, Timbetasin, Timbetasin acetate, RGN-259, RGN-137, RGN-352, NL005, a recombinant Tβ4-related product.

Healing and repair peptides · Full-length actin-binding peptide; related recombinant trial formulations.

It helps control actin, a protein cells use to change shape and move. Lab and animal studies show effects on wound closure, inflammation and new blood vessels. Different parts of the molecule have different actions; those findings cannot predict a useful self-injection dose.

  • G-actin: Binds actin building blocks and helps regulate cell movement.
  • Vessel-growth and cell-survival pathways: Preclinical work links it to angiogenesis and survival after injury.
  • Ac-SDKP breakdown product: A separate four-residue region contributes anti-inflammatory and anti-scarring actions in lab studies.

Half-life: For IV NL005, mean single-dose half-lives were 0.5–2.084 hours across measured dose cohorts.

Related to Thymosin beta-4

Sources

Sources checked: 2026-10-18.

Information only, not medical advice. Peptifacts does not sell anything and does not link to sellers.