What does TB-500 do? Benefits and evidence

A short piece of thymosin beta-4 with no proven repair benefit in humans.

Also called: TB500, Ac-LKKTETQ, Thymosin beta-4 fragment 17–23.

Healing and repair peptides · N-acetylated seven-amino-acid thymosin beta-4 fragment.

TB-500 usually means a seven-amino-acid piece of thymosin beta-4, but products may contain the full peptide. No controlled human trial establishes tendon repair in people. A 2026 three-case dental report used several drugs together without confirming peptide identity. No approved dose or reliable long-term safety data exist.

  • People report injecting it for tendon, muscle and joint recovery, but no controlled human trial has shown a benefit. (Reported by users)
  • Some users report less knee or shoulder pain; others report no change after weeks of daily use. (Reported by users)
  • In animal studies, a related fragment showed a possible repair mechanism, which has not been shown in people. (animal)

Uses in the sources

  • People inject it for tendon, muscle and joint recovery. No controlled human trial establishes benefit for these uses. (Reported by users) (source)
  • A three-case dental report used a product called TB-500 with other drugs after nerve injury. Product identity and its contribution remain unknown. (Clinician-published) (source)

Related to TB-500

Sources

Sources checked: 2026-10-18.

Information only, not medical advice. Peptifacts does not sell anything and does not link to sellers.