TB-500 FAQ: common questions answered
A short piece of thymosin beta-4 with no proven repair benefit in humans.
Also called: TB500, Ac-LKKTETQ, Thymosin beta-4 fragment 17–23.
Healing and repair peptides · N-acetylated seven-amino-acid thymosin beta-4 fragment.
- Is TB-500 FDA-approved? No. TB-500 acetate (acetylated LKKTETQ fragment): limited to subcutaneous, intramuscular forms. The October 30, 2026 Federal Register describes a nonbinding draft interim HHS 503A enforcement policy, with public comment invited. It is conditional on eligible state-licensed pharmacies, federal facilities or licensed physicians, a patient-specific prescription, a single active ingredient, specified identity and route, qualified manufacturing, lot testing, reporting and labeling conditions. It is not FDA drug approval, a final 503A listing or general authorization to supply research products.
- How do people take it? Under the skin, twice weekly. Reported plans commonly span 4–8 weeks.. Source: reported by users, not an established dose.
- What's the difference between TB-500 and BPC-157? TB-500: a short piece of thymosin beta-4 with no proven repair benefit in humans. BPC-157: an experimental repair peptide with mostly animal evidence and a few small human reports. Why people pair them: users call this the Wolverine stack and hope for faster soft-tissue recovery. No controlled human trial of the fragment pair was found.
- Can I take it with BPC-157? Users call this the Wolverine stack and hope for faster soft-tissue recovery. No controlled human trial of the fragment pair was found. Identity uncertainty and two unapproved exposures. A rat combination study found no added benefit. Source: reported by users. Ask a doctor before combining anything.
- Is it banned in sport? Yes. It is banned in and out of competition (WADA 2026). Thymosin-β4 and derivatives, with TB-500 explicitly named.
- How long does a mixed vial last? Forum users refrigerate mixed vials. No validated stability or sterile-use deadline is established.
Related to TB-500
- BPC-157: An experimental repair peptide with mostly animal evidence and a few small human reports.
- GHK-Cu: A copper-binding skin peptide with small topical studies and untested systemic injections.
- AHK-Cu: A copper peptide used in scalp serums, with laboratory findings and weak patent-only human data.
- Thymosin beta-4: A peptide studied for eye conditions and skin wounds; tendon-repair injections lack controlled human evidence.
- ARA-290: Experimental peptide studied for small-fiber nerve damage, with uncertain pain relief and safety.
- Ac-SDKP: An experimental repair peptide with old human studies, but no proven healing dose.
Sources
- 503B Bulk Drug Substances List, FDA · FDA · 2026
- Bulk Drug Substances Used in Compounding Under Section 503A of the FD&C Act, FDA · FDA · 2026
- Cellulitis, NHS · NHS · 2026
- Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks, FDA · FDA · 2026
- Federal Register: nonbinding draft HHS interim policy, October 30 2026, 2026
- HHS 503A peptide interim enforcement policy and conditions, October 30 2026, 2026
- July 23-24, 2026, Meeting of the Pharmacy Compounding Advisory Committee – FDA Briefing Document for TB-500-Related Bulk Drug Substances (TB-500 (free base) and TB-500 acetate), FDA · FDA · 2026
- July 23-24, 2026: Meeting of the Pharmacy Compounding Advisory Committee - 07/23/2026, FDA · FDA · 2026
- Medicines, European Medicines Agency · European Medicines Agency · 2026
- MHRA Products | Home, MHRA · MHRA · 2026
- The 2026 Prohibited List, World Anti-Doping Agency · WADA · 2026
- Therapeutic Goods (Poisons Standard—October 2026) Instrument 2026, Australian Government · Australian Government · 2026
- Think twice before injecting peptides bought online: unauthorized products can seriously harm you, Health Canada · Health Canada · 2026
- Thymosin Beta-4, Sport Integrity Australia · 2026
- Anaphylaxis, NHS · NHS · 2023
Sources checked: 2026-10-18.
Information only, not medical advice. Peptifacts does not sell anything and does not link to sellers.