What does Kisspeptin-10 do? Benefits and evidence

Kisspeptin-10 triggers reproductive hormone release, but home injection benefits and long-term safety remain unproven. Libido and IVF findings for kisspeptin-54 do not establish benefits for kisspeptin-10. Small studies found hormone changes, sometimes including testosterone. A 2026 study tested under-skin infusions for up to 12 days in healthy men. It has no approved dose.

• In small studies in men, an IV dose raised testosterone and LH, the hormone that signals the testes. (Studied in a trial)
• In a small study, pump doses under the skin kept their hormone effect for 12 days. (Studied in a trial)
• Studied as a test of the brain's reproductive signal in delayed puberty and low sex hormone conditions. (Studied in a trial)
• People report stronger libido or fuller testes, but no one confirmed it with tests. (Reported by users)

Uses in the sources

• Studied as a probe of GnRH function in hypogonadism and delayed puberty. Some congenital cases do not respond. (Studied in a trial) (source)
• Studied for hormone stimulation in high prolactin, PCOS and low testosterone with type 2 diabetes. Clinical benefits remain unproven. (Studied in a trial) (source)
• Used online for libido and as a proposed hCG alternative during TRT. Improved fertility or sexual function has not been established for KP-10. (Reported by users) (source)
• Investigated for oxytocin and vasopressin diagnostic testing; this does not establish a treatment for either deficiency. (Studied in a trial) (source)