Kisspeptin-10 research: studies, doses and safety

A short-acting experimental peptide that triggers reproductive hormone release.

Also called: KP-10, KP10, Kisspeptin 112-121, Metastin 45-54, NSC 741805.

Reproductive axis peptides · KISS1 receptor agonist.

Early studies in healthy men tested single IV doses or infusions lasting up to 22.5 hours, rather than multiweek home-injection cycles.

38 human research records include ongoing studies and studies without results; some share participants. Most measured short-term hormones, not lasting benefits or long-term safety.

Key studies

  • A bolus resets LH timing: One IV dose triggered an LH pulse and delayed the next spontaneous pulse. (source)
  • First dose and infusion study: IV dosing raised LH and testosterone; these experiments did not test home injection schedules. (source)
  • Response depends on sex and cycle: KP-10 cleared in minutes; women responded differently across the cycle. (source)
  • Cycle phase changes the LH response: Responses to the same dose varied by menstrual phase. (source)
  • Contraception changes the response: Combined-pill users had a blunted LH response. (source)
  • NKB-deficient patients respond to infusion: Continuous KP-10 restored LH pulses in four selected patients. (source)

Related to Kisspeptin-10

Sources

Sources checked: 2026-10-18.

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