What does Humanin do? Benefits and evidence

A peptide the body makes; injection benefits and safety remain unproven.

Also called: HN, MT-RNR2 peptide.

Mitochondrial-derived peptides · 24-amino-acid mitochondrial cell-survival peptide.

Humanin is a peptide the body makes, studied for cell protection. Injection benefits and safety remain unproven. People use it hoping for longevity, better sleep or brain protection. Human studies measure natural levels. Dosing and cancer effects remain unresolved.

  • In animal studies, it lengthened lifespan in worms and improved some health measures in mice; this has not been tested in people. (animal)
  • In lab studies, humanin protected nerve cells from several kinds of damage linked to Alzheimer's disease. (animal)
  • A few people report longer, unbroken sleep, but no human trial has tested humanin for sleep. (Reported by users)

Uses in the sources

  • Users seek longevity benefits. Lifespan findings come from worms and other laboratory models, not human treatment trials. (Reported by users) (source)
  • A few users report better sleep. No human trial has tested humanin for sleep. (Reported by users) (source)
  • Users discuss brain protection; cell and mouse findings do not establish improved cognition in people taking humanin. (Reported by users) (source)

Related to Humanin

Sources

Sources checked: 2026-10-18.

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