Humanin research: studies, doses and safety

A peptide the body makes; injection benefits and safety remain unproven.

Also called: HN, MT-RNR2 peptide.

Mitochondrial-derived peptides · 24-amino-acid mitochondrial cell-survival peptide.

No verified direct-administration human studies in the reviewed record. Human biomarker studies and experiments administering humanin to animals are separate evidence.

Key studies

  • Severe Klebsiella infection: Serum humanin was higher during infection, p<0.001. Treatment experiments were in mice, not patients. (source)
  • Heart-failure rehabilitation: At 6 months, cardiac events occurred in 24/71 vs 41/83, p=0.051. The humanin/CRP ratio was an observational risk marker. (source)
  • Water exercise in older women: The study measured humanin after 12 weeks of training; its abstract reports no separate humanin effect estimate. (source)
  • Hemodialysis risk models: 33 had a cardiovascular event; both low <462 and high >778 pg/mL humanin were linked to increased risk. (source)
  • Exercise and astaxanthin: Humanin rose after combined exercise with or without astaxanthin, p<0.05. No humanin injections were used. (source)
  • PCOS serum and muscle: Median humanin was 474.9 vs 672.3 pg/mL, p<0.001; muscle levels did not differ, p=0.71. (source)

Related to Humanin

Sources

Sources checked: 2026-10-18.

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