How Humanin works

A peptide the body makes; injection benefits and safety remain unproven.

Also called: HN, MT-RNR2 peptide.

Mitochondrial-derived peptides · 24-amino-acid mitochondrial cell-survival peptide.

Humanin can reduce signals that tell stressed cells to die. Cell studies show it interacts with Bax and a cell-surface receptor complex. Keeping cells alive may also help some tumors, so cell protection does not establish safety.

  • Bax and related cell-death proteins: Can block movement of Bax to mitochondria in laboratory models.
  • CNTFR/WSX-1/gp130 complex: Activates cell-survival signaling in neuronal-cell experiments.
  • IGFBP-3: Binds a protein involved in growth-factor and cell-death signaling; effects depend on context.

Half-life: Human pharmacokinetics are unknown. Often-quoted short half-lives come from animal/analog work.

Related to Humanin

Sources

Sources checked: 2026-10-18.

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