How Thymogen works
A Russian peptide used for immune problems, with negative cancer trials.
Also called: Timogen, Thymagen, L-Glu-L-Trp, Glu-Trp, EW, Alpha-glutamyl-tryptophan, Oglufanide, IM862, IM-862.
Khavinson bioregulator peptides · Synthetic L-glutamyl-L-tryptophan immune-modulating dipeptide.
It can change how immune cells mature and signal. Cell and animal studies suggest effects on T cells, natural killer cells and inflammation. These findings do not show that it rebuilds a human thymus.
- T-cell development and signaling: Proposed changes in immune-cell maturation and activity; a single validated human receptor is not established.
- Natural killer cells and perforin: Required for antitumor effects in mouse experiments; human cancer trials were negative.
- Inflammatory cell signals: Cultured-cell studies show changes in TNF and IL-6 responses.
Half-life: No reliable human elimination half-life verified.
Related to Thymogen
- Epitalon: A peptide with telomerase effects in cells, but no proof that people live longer.
- Pinealon: A peptide with unproven brain benefits and no established injection dose.
- Thymalin: A calf thymus extract studied for immune problems, with uncertain safety and product identity.
- Vesugen: An experimental blood-vessel peptide with unclear benefits and poorly defined safety.
- Cortagen: A four-amino-acid brain peptide backed mainly by animal work and unverified patent claims.
- BPC-157: An experimental repair peptide with mostly animal evidence and a few small human reports.
Sources
- Bulk Drug Substances Used in Compounding, FDA · 2026
- Medicines, European Medicines Agency · European Medicines Agency · 2026
- MHRA Products | Home, MHRA · MHRA · 2026
- Pyrogen and Endotoxins Testing: Questions and Answers, FDA · 2026
- TGA warning on the risks of importing unapproved peptide products, Therapeutic Goods Administration · 2026
- The 2026 Prohibited List, World Anti-Doping Agency · WADA · 2026
- Darmerica, LLC - 716152 - 12/08/2025, FDA · FDA · 2025
- Инструкция по медицинскому применению лекарственного препарата Регастим Гастро, Министерство здравоохранения Российской Федерации · 2023
- Тимоген р-р для в/м инъекций - Цитомед - инструкция по применению, 2023
- Тимоген спрей - Цитомед - инструкция по применению, 2011
- Тимоген: крем для наружного применения. Инструкция по медицинскому применению препарата, 2007
- Q6A Specifications: Test Procedures and Acceptance Criteria for New Drug Substances and New Drug Products: Chemical Substances, FDA · FDA · 2000
- Drug Product Database online query
- OGLUFANIDE SODIUM
- Alpha-glutamyl-tryptophan as adjuvant reparative therapy after Helicobacter pylori eradication in chronic atrophic gastritis: A case report and literature review, 2026
Sources checked: 2026-10-18.
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