Mechano growth factor research: studies, doses and safety

A muscle-repair peptide idea with mixed lab findings and no human dosing studies.

Also called: MGF, Non-PEG MGF, MGF E peptide, MGF-Ct24E, IGF-1Ec E-domain peptide.

IGF-1 splice variants · Synthetic E-domain peptide associated with IGF-1Ec · Evidence: Animal studies only.

No human administration study found. Human-derived cell work and animal findings are mixed; they do not establish dosing.

Key studies

  • Early muscle-cell findings: An early experiment reported more muscle-cell growth and delayed maturation with the MGF E-domain. (source)
  • Human muscle cells transplanted into mice: MGF peptide improved human-cell engraftment in mice, not in human recipients. (source)
  • Human muscle cells in a dish: MGF-E affected younger donor cells in culture; it was never administered to the donors. (source)
  • MGF effects failed replication: MGF fragments did not reproduce the muscle-cell effects reported in earlier work. (source)
  • Injured Achilles tendon in rats: An MGF-related peptide improved measures of tendon healing in rats. (source)
  • MGF analogue after a mouse heart attack: A stabilized MGF analogue improved heart pumping measures, but did not prevent heart enlargement. (source)

Related to Mechano growth factor (MGF)

Sources

Sources checked: 2026-10-18.

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