How Mechano growth factor works
A muscle-repair peptide idea with mixed lab findings and no human dosing studies.
Also called: MGF, Non-PEG MGF, MGF E peptide, MGF-Ct24E, IGF-1Ec E-domain peptide.
IGF-1 splice variants · Synthetic E-domain peptide associated with IGF-1Ec · Evidence: Animal studies only.
The IGF-1 gene can make several versions of a growth protein. MGF products usually contain a short fragment from one version. Some lab studies suggest it changes cell growth or movement, but its receptor and effects remain disputed.
- MGF E-domain signalling: Some cell studies report growth or movement signals through ERK. An independent study failed to reproduce key effects.
- IGF-1 receptor: A direct receptor target for the isolated E peptide is not established. It is not interchangeable with mature IGF-1.
Half-life: No human half-life has been established.
Related to Mechano growth factor (MGF)
- PEG-MGF: A modified MGF peptide with no human dosing studies and uncertain identity in unregulated vials.
- IGF-1 LR3: An unapproved growth signal with no human trials found.
Sources
- 503B Bulk Drug Substances List, FDA · FDA · 2026
- Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the Federal Food, Drug, and Cosmetic Act, FDA · FDA · 2026
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- Peptide products, Therapeutic Goods Administration · TGA · 2026
- Pyrogen and Endotoxins Testing: Questions and Answers, FDA · 2026
- The 2026 Prohibited List, World Anti-Doping Agency · WADA · 2026
- Therapeutic Goods (Poisons Standard—October 2026) Instrument 2026, Australian Government · Australian Government · 2026
- Think twice before injecting peptides bought online: unauthorized products can seriously harm you, Health Canada · Health Canada · 2026
- Supply unlicensed medicinal products (specials), MHRA · 2025
- Using intramuscular injections in people on oral anticoagulants, NHS Specialist Pharmacy Service · NHS Specialist Pharmacy Service · 2023
- Q6A Specifications: Test Procedures and Acceptance Criteria for New Drug Substances and New Drug Products: Chemical Substances, FDA · FDA · 2000
- Anaphylaxis: MedlinePlus Medical Encyclopedia, MedlinePlus · MedlinePlus
- Low Blood Glucose (Hypoglycemia), National Institute of Diabetes and Digestive and Kidney Diseases
- Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise., Hameed M et al. · The Journal of physiology · 2003
- The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration., Dominikowski A et al. · Frontiers in endocrinology · 2026
Sources checked: 2026-10-18.
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