What does KPV do? Benefits and evidence

An alpha-MSH fragment studied for gut inflammation in animals, with no human dosing trial.

Also called: Lys-Pro-Val, Lysine-proline-valine, alpha-MSH(11-13), KPV acetate.

Anti-inflammatory and antimicrobial peptides · C-terminal alpha-MSH tripeptide with preclinical anti-inflammatory activity · Evidence: Animal studies only.

KPV is a three-amino-acid fragment of alpha-MSH. Gut-inflammation findings come from cells and animals, including mice given KPV by mouth. No published human dosing, benefit or safety study was found. People report oral and injected use, but neither has an established human dose. Product identity and long-term risks remain uncertain.

  • In mouse studies, it reduced gut inflammation, including in mice given it by mouth. (animal)
  • A few users report gut-symptom relief or less bloating; another reported no clear benefit. (Reported by users)
  • In an animal study, it sped healing of wounds on the eye surface in rabbits. (animal)

Uses in the sources

  • People report using it for gut symptoms and inflammation. The supporting colitis experiments are in mice, not human trials. (Reported by users) (source)
  • Topical wound and skin uses are discussed, but FDA found no human effectiveness studies. Rabbit eye-wound results do not support home eye drops. (Reported by users) (source)

Related to KPV

Sources

Sources checked: 2026-10-18.

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