Glutathione dosage: reported doses and schedule
An antioxidant with mixed oral evidence and important risks from compounded injections.
Also called: GSH, Reduced L-glutathione, L-glutathione, GSSG, oxidized glutathione.
Antioxidant peptides · Endogenous thiol antioxidant; chemically a gamma-glutamyl tripeptide.
Typical reported dose: 100 mg about five times a week
- IV clearance (Aebi 1991): 2 g/m² IV once one infusion, into a vein. Studied in a trial. Studied in: Healthy volunteers. (source)
- IV metabolite study (Hong 2005): 50 mg/kg IV over 10 minutes once one infusion, into a vein. Studied in a trial. Studied in: Seven healthy men aged 22–23. (source)
- Oral 1 g for four weeks: 500 mg twice daily; total 1,000 mg/day twice daily, by mouth. Studied in a trial. Studied in: Healthy adults. (source)
- Oral 250 or 1,000 mg: 250 mg/day daily, by mouth. Studied in a trial. Studied in: Healthy nonsmoking adults. (source)
- Oral 250 or 1,000 mg: 1000 mg/day daily, by mouth. Studied in a trial. Studied in: Healthy nonsmoking adults. (source)
- Liposomal 500 or 1,000 mg: 500 mg liposomal glutathione daily daily, by mouth. Studied in a trial. Studied in: Healthy nonsmokers aged 50–80. (source)
These are doses reported in labels, trials or user reports, not a personal plan. Check the source behind each one.
Related to Glutathione
- NAD+ and precursors: NAD+ helps cells use energy; wellness injection benefits remain unproven.
Sources
- 503B Bulk Drug Substances List, FDA · FDA · 2026
- Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the Federal Food, Drug, and Cosmetic Act, FDA · FDA · 2026
- FDA reminds compounders not to use dietary supplement grade glutathione for injectables, FDA · 2026
- Find product information about medicines, Medicines and Healthcare products Regulatory Agency · MHRA · 2026
- The 2026 Prohibited List, World Anti-Doping Agency · WADA · 2026
- Bulk Drug Substances Nominated for Use in Compounding Under Section 503B of the Federal Food, Drug, and Cosmetic Act, FDA · FDA · 2025
- Advertising guidance for businesses involved with intravenous (IV) vitamin and related therapies: Complying with therapeutic goods advertising requirements, Therapeutic Goods Administration · 2023
- Pharmacy Compounding Advisory Committee Meeting June 8, 2022 Summary Minutes, FDA · 2022
- 30ml Reduced-Glutathione 200mg/ml (2020-11-13), Health Canada · 2020
- FDA highlights concerns with using dietary ingredient glutathione to compound sterile injectables, FDA · 2019
- BSS PLUS- balanced salt solution enriched with bicarbonate, dextrose, and glutathione kit, Alcon Laboratories, Inc. · DailyMed
- EU/3/06/361 - orphan designation for treatment of cystic fibrosis, European Medicines Agency
- Product information, Health Canada
- Validation of an HPLC-UV method for the analysis of glutathione and its impurities, FDA
- A cluster analysis of 466 patients demonstrates that glutathione supplementation could preferentially benefit advanced unstable cirrhosis phenotype rather than stable cirrhosis., Philips CA et al. · Frontiers in pharmacology · 2026
Sources checked: 2026-10-18.
Information only, not medical advice. Peptifacts does not sell anything and does not link to sellers.