What does Dihexa do? Benefits and evidence

An experimental memory compound with disputed animal research and no established human dose.

Also called: PNB-0408, N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide.

Nootropic peptides · Modified angiotensin IV peptide; proposed HGF/MET modulator · Evidence: Animal studies only.

Dihexa is an experimental memory peptide studied in animals and lab cells, with no direct human study identified. A key paper was retracted and the original development paper has a notice of concern; long-term safety is unknown, including a theoretical concern about cancer growth.

  • In animal studies it was explored as a memory drug; one mouse study reported benefit, but a key early paper was retracted. (animal)
  • People report more creativity, focus, learning or energy, though these are personal impressions and one user felt nothing. (Reported by users)
  • Some people report trying it after a concussion, but no trial has shown that taking it helps. (Reported by users)

Uses in the sources

  • People report using it for learning, memory and creativity. These reports do not establish benefit. (Reported by users) (source)
  • Some people self-experiment after concussion or cognitive symptoms. No trial has established benefit from directly taking dihexa. (Reported by users) (source)

Related to Dihexa

Sources

Sources checked: 2026-10-18.

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