How Dihexa works
An experimental memory compound with disputed animal research and no established human dose.
Also called: PNB-0408, N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide.
Nootropic peptides · Modified angiotensin IV peptide; proposed HGF/MET modulator · Evidence: Animal studies only.
It was designed to help nerve cells connect through HGF and MET growth signals. Early papers carry retraction and concern notices. Later rat findings and related fosgonimeton trials do not establish human benefits from taking dihexa.
- HGF/MET growth signaling: Proposed increase in nerve-cell connections. The foundational mechanism evidence is disputed.
- PI3K/AKT signaling: Changed in a mouse study; this does not prove a direct drug target in people.
Half-life: Unknown after direct dosing in humans. Long rat estimates come from a paper with a notice of concern.
Related to Dihexa
- Semax: A Russian nasal peptide with limited human evidence for brain and nerve effects.
- Selank: A Russian nasal anxiety peptide with uncertain long-term benefit and safety.
- PE-22-28: An experimental mood peptide studied in mice, with no human trials found.
- P21: An experimental memory peptide with animal research and no established human dose or safety profile.
- Cerebrolysin: An injectable pig brain mixture with mixed stroke, brain-injury and dementia evidence.
Sources
- 503B Bulk Drug Substances List, FDA · FDA · 2026
- Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the Federal Food, Drug, and Cosmetic Act, FDA · FDA · 2026
- Bulk Drug Substances Used in Compounding Under Section 503A of the FD&C Act, FDA · FDA · 2026
- Cellulitis, NHS · NHS · 2026
- Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks, FDA · FDA · 2026
- Medicines, European Medicines Agency · European Medicines Agency · 2026
- Meeting of the Pharmacy Compounding Advisory Committee, FDA · 2026
- MHRA Products | Home, MHRA · MHRA · 2026
- TGA strengthens compliance focus on unapproved peptide products as part of evolving risk response, Therapeutic Goods Administration · TGA · 2026
- The 2026 Prohibited List, World Anti-Doping Agency · WADA · 2026
- Think twice before injecting peptides bought online: unauthorized products can seriously harm you, Health Canada · Health Canada · 2026
- <797> FAQs, United States Pharmacopeia · 2023
- Anaphylaxis, NHS · NHS · 2023
- Drug Product Database: Access the database, Health Canada · Health Canada
- Drugs@FDA Data Files, FDA
Sources checked: 2026-10-18.
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