What does 5-amino-1MQ do? Benefits and evidence

An experimental NNMT blocker with animal findings, no human dosing trials and uncertain risks.

Also called: 5-Amino-1MQ, 5-amino-1-methylquinolinium, 5A1MQ, 5-AMQ, 5A-1MQ, 5-amino-1-methylquinolinium iodide, 5-amino-1-methylquinolinium chloride.

NNMT inhibitors · Small-molecule nicotinamide N-methyltransferase inhibitor · Evidence: Animal studies only.

5-amino-1MQ is a small molecule, not a peptide. People use it for fat loss and energy, but controlled benefits come from animals and cells. No human dosing or efficacy trial was found. A mixed-drug human harm report exists, and online product quality adds risk.

  • In mice, it lowered weight and fat stores without a clear drop in how much they ate. (animal)
  • In old mice, it improved muscle repair after injury, and in another mouse study grip strength improved. (animal)
  • People report using it for fat loss and more energy, though some notice no effect; it has never been tested in human trials. (Reported by users)

Uses in the sources

  • People report using it for fat loss. Mouse results do not establish weight loss in people. (Reported by users) (source)
  • Users report more energy or no effect. No controlled human energy study was found. (Reported by users) (source)
  • Used in body-composition stacks; muscle-function findings are from aged mice. (Reported by users) (source)

Related to 5-amino-1MQ

Sources

Sources checked: 2026-10-18.

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