5-amino-1MQ research: studies, doses and safety

An experimental NNMT blocker with animal findings, no human dosing trials and uncertain risks.

Also called: 5-Amino-1MQ, 5-amino-1-methylquinolinium, 5A1MQ, 5-AMQ, 5A-1MQ, 5-amino-1-methylquinolinium iodide, 5-amino-1-methylquinolinium chloride.

NNMT inhibitors · Small-molecule nicotinamide N-methyltransferase inhibitor · Evidence: Animal studies only.

Efficacy evidence is preclinical. One mixed-drug human harm vignette; no human dosing, PK or efficacy trials found.

Key studies

  • Obese mice: 11 days: Weight and fat-pad mass fell in mice without a clear fall in food intake. (source)
  • Aged mice after muscle injury: An injury model in old mice showed better muscle regeneration. (source)
  • Rat absorption and clearance: Oral absorption was measurable in rats, not established in people. (source)
  • Diet switch plus NNMT blockade: The combination outperformed diet change alone in mice. (source)
  • Mouse microbiome after diet switch: The microbiome pattern differed after combined diet change and NNMT blockade. (source)
  • Aged female mice with exercise: Grip strength improved, but other muscle measures did not uniformly improve. (source)

Related to 5-amino-1MQ

Sources

Sources checked: 2026-10-18.

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