VIP dosage: reported doses and schedule
A blood-vessel and immune signal studied in lung disease; nasal CIRS benefits remain unproven.
Also called: Vasoactive intestinal peptide, Vasoactive intestinal polypeptide, Aviptadil, RLF-100, Zyesami.
Immune peptides · VPAC1 and VPAC2 receptor agonist.
Typical reported dose: One 50 mcg spray in one nostril, four times a day
- Three monitored IV infusion days: Day 1: 50 pmol/kg/hour for 12 hours, then Day 2: 100 pmol/kg/hour for 12 hours, then Day 3: 150 pmol/kg/hour for 12 hours one 12-hour infusion daily for 3 successive days, into a vein. Studied in a trial. Studied in: Adults in the cited study. (source)
- Three monitored IV infusion days: Day 1: 50 pmol/kg/hour for 12 hours, then Day 2: 100 pmol/kg/hour for 12 hours, then Day 3: 150 pmol/kg/hour for 12 hours one 12-hour infusion daily for 3 successive days, into a vein. Studied in a trial. Studied in: Adults in the cited study. (source)
- India trial: three infusion days: Day 1: 0.166 mcg/kg/hour for 12 hours, then Day 2: 0.332 mcg/kg/hour for 12 hours, then Day 3: 0.498 mcg/kg/hour for 12 hours one 12-hour infusion daily for 3 successive days, into a vein. Studied in a trial. Studied in: Adults in the cited study. (source)
- Two inhalations 30 minutes apart: 100 mcg in 1 mL, then another 100 mcg in 1 mL after 30 minutes; total 200 mcg/day one daily session with two inhalations, inhaled. Studied in a trial. Studied in: Adults in the cited study. (source)
- Sarcoidosis: 50 mcg four times daily: 50 mcg by ultrasonic nebulizer four times daily four times daily, inhaled. Studied in a trial. Studied in: Adults in the cited study. (source)
- Pulmonary hypertension: four inhalations: 50 mcg per inhalation, four times daily; total 200 mcg/day four times daily, inhaled. Studied in a trial. Studied in: Adults in the cited study. (source)
These are doses reported in labels, trials or user reports, not a personal plan. Check the source behind each one.
Related to VIP
- Thymosin alpha-1: An immune-signaling peptide with overseas approvals and mixed trial results.
- KPV: An alpha-MSH fragment studied for gut inflammation in animals, with no human dosing trial.
Sources
- Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the Federal Food, Drug, and Cosmetic Act, FDA · FDA · 2026
- Bulk Drug Substances Used in Compounding Under Section 503A of the FD&C Act, FDA · FDA · 2026
- EU/3/26/3200 - orphan designation for treatment of acute respiratory distress syndrome (ARDS), 2026
- Pyrogen and Endotoxins Testing: Questions and Answers, FDA · 2026
- The Prohibited List, World Anti-Doping Agency · World Anti-Doping Agency · 2026
- Therapeutic Goods (Poisons Standard—October 2026) Instrument 2026, Australian Government · Australian Government · 2026
- Think twice before injecting peptides bought online: unauthorized products can seriously harm you, Health Canada · Health Canada · 2026
- Interim Policy on Compounding Using Bulk Drug Substances Under Section 503A of the Federal Food, Drug, and Cosmetic Act, 2025
- Amendments to the List of Bulk Drug Substances That Can Be Used to Compound Drug Products in Accordance With Section 503A of the Federal Food, Drug, and Cosmetic Act, 2019
- AWMSG Secretariat Assessment Report. Aviptadil/phentolamine mesilate (Invicorp) 25 micrograms/2 mg solution for injection, 2017
- Q6A Specifications: Test Procedures and Acceptance Criteria for New Drug Substances and New Drug Products: Chemical Substances, FDA · FDA · 2000
- Search Orphan Drug Designations and Approvals, FDA · FDA
- VALMISTEYHTEENVETO
- INTRAVENOUS AVIPTADIL AS ADJUNCTIVE THERAPY IN ACUTE RESPIRATORY DISTRESS SYNDROME: AN OBSERVATIONAL CASE SERIES OF SIX PATIENTS, 2026
- Aviptadil Therapy in Acute Respiratory Distress Syndrome Patients: A Systematic Review and Meta-analysis., Udupa AA et al. · Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025
Sources checked: 2026-10-18.
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