How Somatropin works
Prescription human growth hormone, with no proven anti-aging benefit.
Also called: HGH, hGH, rhGH, recombinant human growth hormone, Genotropin, Humatrope, Norditropin, Omnitrope, Saizen, Zomacton, Serostim, Zorbtive, Nutropin AQ.
Growth hormone · Recombinant human growth hormone receptor agonist · Evidence: Approved drug.
It replaces GH directly, unlike peptides that ask the pituitary to release more. GH helps the body use fat and signals the liver and other tissues to make IGF-1, which supports growth. Too much can cause fluid buildup and make insulin work less well.
- Growth hormone receptor: Triggers growth signals and changes how the body uses protein, fat and sugar.
- IGF-1 pathway: Increases IGF-1 production in the liver and other tissues; supports bone and tissue growth.
Half-life: Genotropin: about 3 hours after an SC injection in adults with GHD; about 0.4 hours after IV dosing.
Related to Somatropin
- Retatrutide: An experimental weekly injection with phase 3 weight-loss results.
- BPC-157: An experimental repair peptide with mostly animal evidence and a few small human reports.
- TB-500: A short piece of thymosin beta-4 with no proven repair benefit in humans.
- Ipamorelin: An experimental peptide that triggers growth hormone release.
Sources
- Import Alert 66-71, 2026
- Saizen, 2026
- The 2026 Prohibited List, World Anti-Doping Agency · WADA · 2026
- ACMD advice on somapacitan, lonapegsomatropin and somatrogon (accessible), 2025
- DailyMed - NUTROPIN AQ NUSPIN 5- somatropin injection, solution NUTROPIN AQ NUSPIN 10- somatropin injection, solution NUTROPIN AQ NUSPIN 20- somatropin injection, solution, 2025
- Genentech Provides Update on Nutropin AQ (somatropin) NuSpin formulations in the United States, 2024
- SAIZEN (somatropin) for injection, for subcutaneous use, 2020
- AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF GROWTH HORMONE DEFICIENCY IN ADULTS AND PATIENTS TRANSITIONING FROM PEDIATRIC TO ADULT CARE., Yuen KCJ et al. · Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2019
- Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline., Molitch ME et al. · The Journal of clinical endocrinology and metabolism · 2011
- DailyMed - GENOTROPIN- somatropin kit
- DailyMed - HUMATROPE- somatropin kit
- DailyMed - NORDITROPIN- somatropin injection, solution
- DailyMed - OMNITROPE- somatropin injection, solution OMNITROPE- somatropin kit
- DailyMed - SEROSTIM- somatropin kit
- DailyMed - ZOMACTON- somatropin kit
Sources checked: 2026-10-18.
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