What does Sermorelin do? Benefits and evidence

Sermorelin prompts the pituitary gland to release growth hormone. Geref was approved for GH testing and childhood GH deficiency, then discontinued. Small adult studies show hormone changes and some limited benefits, but do not establish better sleep, muscle gain or longer life. Current compounded products are not FDA-approved. Product quality and unknown long-term effects matter.

• In a small HIV trial, people gained some lean mass and lost some trunk fat. (Studied in a trial)
• In a small study of older adults, some thinking tests improved. (Studied in a trial)
• People report better sleep, though others report early waking or no change. (Reported by users)
• As Geref, it was once approved to treat slow growth in children with growth hormone deficiency; that approval was withdrawn. (Drug label)

Uses in the sources

• Historical Geref approvals covered pituitary GH testing and growth failure in children with idiopathic GH deficiency. (Drug label) (source)
• A small HIV lipodystrophy trial found more lean mass and less trunk fat; the visceral-fat difference was not statistically clear. (Studied in a trial) (source)
• Small older-adult and acute memory studies found changes in selected thinking tests. Dementia prevention was not demonstrated. (Studied in a trial) (source)
• Users report better sleep, but others report early waking or no benefit. Preliminary controlled sleep results did not show improvement. (Reported by users) (source)
• Used in hopes of muscle gain and recovery. Adult studies mainly measured hormones; consistent strength or recovery benefits remain unproven. (Reported by users) (source)