Sermorelin dosage: reported doses and schedule
An experimental short-acting peptide that triggers growth hormone release, with limited evidence of adult benefits.
Also called: Sermorelin acetate, Geref, GHRH(1-29)-NH2, GRF(1-29)-NH2, Groliberin.
GHRH analogues · Growth hormone-releasing hormone receptor agonist.
Typical reported dose: Historical pediatric label: 30 mcg per kg at bedtime
- Historical Geref pediatric label: A dosage of 0.03 mg (30 mcg) per kg of body weight once daily at bedtime by subcutaneous injection is recommended. once daily, under the skin. Drug label. Studied in: Prepubertal children with growth failure from idiopathic GH deficiency and adequate Geref stimulation response; historical exclusion: peak GH < 2 ng/mL. (source)
- Specialist GH stimulation test: 1 mcg/kg IV once, with arginine under a specialist testing protocol. single supervised diagnostic dose, into a vein. Clinician-published. Studied in: Adults being assessed for GH deficiency. (source)
- Geref study: 30 mcg/kg nightly: 30 mcg/kg SC at bedtime once daily, under the skin. Studied in a trial. Studied in: Previously untreated, prepubertal children with GH deficiency. (source)
- Older men: 0.5 mg twice daily: 0.5 mg SC per injection twice daily, under the skin. Studied in a trial. Studied in: 10 older men, mean 68 years; 9 young men as baseline comparators. (source)
- Older men: 1 mg twice daily: 1 mg SC per injection twice daily, under the skin. Studied in a trial. Studied in: 10 older men, mean 68 years; 9 young men as baseline comparators. (source)
- Older men: 2 mg nightly: 2 mg SC nightly once daily, under the skin. Studied in a trial. Studied in: Healthy non-obese men aged 64–76 with low IGF-I. (source)
Highest studied: 2 mg SC nightly studied for 6 weeks in 11 older men; not a safety ceiling.; 1 mg SC twice daily studied for 12 weeks in HIV lipodystrophy..
These are doses reported in labels, trials or user reports, not a personal plan. Check the source behind each one.
Related to Sermorelin
- CJC-1295 without DAC: A peptide intended to trigger growth hormone release, with no human dosing study found.
- Tesamorelin: A peptide approved for deep abdominal fat in adults with HIV lipodystrophy.
- CJC-1295 with DAC: An experimental long-acting peptide that triggers growth hormone release, with no proven muscle or recovery benefit.
- Tirzepatide: A weekly GIP/GLP-1 injection with strong diabetes and weight-loss evidence and common stomach side effects.
- BPC-157: An experimental repair peptide with mostly animal evidence and a few small human reports.
- Ipamorelin: An experimental peptide that triggers growth hormone release.
Sources
- 503B Bulk Drug Substances List, FDA · FDA · 2026
- Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the Federal Food, Drug, and Cosmetic Act, FDA · FDA · 2026
- Bulk Drug Substances Used in Compounding Under Section 503A of the FD&C Act, FDA · FDA · 2026
- Compounding and the FDA: Questions and Answers, FDA · FDA · 2026
- Search Results - (emc), 2026
- The 2026 Prohibited List, World Anti-Doping Agency · WADA · 2026
- Therapeutic Goods (Poisons Standard—October 2026) Instrument 2026, Australian Government · Australian Government · 2026
- Bulk Drug Substances Nominated for Use in Compounding Under Section 503B of the Federal Food, Drug, and Cosmetic Act, FDA · FDA · 2025
- Unauthorized injectable peptide drugs seized and sold by Canada Peptide may pose serious health risks, 2025
- October 29, 2024 Meeting of the Pharmacy Compounding Advisory Committee, FDA · 2024
- Xcel Research LLC - 694608 - 12/10/2024, 2024
- Innoveix Pharmaceuticals Inc - 624782 - 01/26/2022, 2022
- Determination That GEREF (Sermorelin Acetate) Injection, 0.5 Milligrams Base/Vial and 1.0 Milligrams Base/Vial, and GEREF (Sermorelin Acetate) Injection, 0.05 Milligrams Base/Amp, Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness, 2013
- Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline., Molitch ME et al. · The Journal of clinical endocrinology and metabolism · 2011
- Geref (Seristim), 2005
Sources checked: 2026-10-18.
Information only, not medical advice. Peptifacts does not sell anything and does not link to sellers.