Sermorelin dosage: reported doses and schedule

An experimental short-acting peptide that triggers growth hormone release, with limited evidence of adult benefits.

Also called: Sermorelin acetate, Geref, GHRH(1-29)-NH2, GRF(1-29)-NH2, Groliberin.

GHRH analogues · Growth hormone-releasing hormone receptor agonist.

Typical reported dose: Historical pediatric label: 30 mcg per kg at bedtime

  • Historical Geref pediatric label: A dosage of 0.03 mg (30 mcg) per kg of body weight once daily at bedtime by subcutaneous injection is recommended. once daily, under the skin. Drug label. Studied in: Prepubertal children with growth failure from idiopathic GH deficiency and adequate Geref stimulation response; historical exclusion: peak GH < 2 ng/mL. (source)
  • Specialist GH stimulation test: 1 mcg/kg IV once, with arginine under a specialist testing protocol. single supervised diagnostic dose, into a vein. Clinician-published. Studied in: Adults being assessed for GH deficiency. (source)
  • Geref study: 30 mcg/kg nightly: 30 mcg/kg SC at bedtime once daily, under the skin. Studied in a trial. Studied in: Previously untreated, prepubertal children with GH deficiency. (source)
  • Older men: 0.5 mg twice daily: 0.5 mg SC per injection twice daily, under the skin. Studied in a trial. Studied in: 10 older men, mean 68 years; 9 young men as baseline comparators. (source)
  • Older men: 1 mg twice daily: 1 mg SC per injection twice daily, under the skin. Studied in a trial. Studied in: 10 older men, mean 68 years; 9 young men as baseline comparators. (source)
  • Older men: 2 mg nightly: 2 mg SC nightly once daily, under the skin. Studied in a trial. Studied in: Healthy non-obese men aged 64–76 with low IGF-I. (source)

Highest studied: 2 mg SC nightly studied for 6 weeks in 11 older men; not a safety ceiling.; 1 mg SC twice daily studied for 12 weeks in HIV lipodystrophy..

These are doses reported in labels, trials or user reports, not a personal plan. Check the source behind each one.

Work out syringe units with the dosing calculator

Related to Sermorelin

Sources

Sources checked: 2026-10-18.

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