Oxytocin results: what to expect and when

A hormone used during childbirth; nasal social and weight-loss benefits remain unproven.

Also called: Pitocin, Syntocinon, OT, OXT, TTA-121.

Neuropeptides · Oxytocin-receptor agonist and uterotonic hormone · Evidence: Approved drug.

Approved Pitocin use is short-term care around childbirth, with treatment length set by the hospital team.

A 2011 review covered 38 separate nasal-spray trials. This is a minimum count that leaves out later research and childbirth trials.

Key studies

  • Preventing bleeding after birth: Preventive oxytocin reduced bleeding versus placebo or no uterotonic. (source)
  • Cochrane update: 122 birth trials: The updated birth-prevention review supports oxytocin as a standard comparator. (source)
  • Trust in a laboratory game: A laboratory trust effect helped launch social-cognition research. (source)
  • Adults with autism: 6 weeks: Primary outcomes were negative; some secondary measures improved. (source)
  • Adult autism crossover: 6 weeks: A small crossover trial found better social-reciprocity scores. (source)
  • Autism dose finding: 16 or 32 IU/day: Neither dose improved the overall trial population. (source)

Sources

Sources checked: 2026-10-18.

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