What does MK-677 do? Benefits and evidence

MK-677 is an oral small molecule, not a peptide. Trials found higher growth hormone and IGF-1, but better strength or recovery did not reliably follow. It can raise blood sugar, increase hunger and cause swelling. A hip-fracture trial stopped early over heart-failure concerns. Pediatric growth trials remain separate from adult self-use.

• In a trial of older adults, it raised lean body mass, though strength and function did not improve. (Studied in a trial)
• Studies show it raises growth hormone and IGF-1 in the blood; better strength or recovery did not reliably follow. (Studied in a trial)
• Small, short studies found changes in deep and REM sleep; long-term sleep benefit is unknown. (Studied in a trial)
• People report better sleep and an easier time eating more. (Reported by users)

Uses in the sources

• Studied for lean mass in older adults and men with obesity. More lean mass did not reliably improve strength or function. (Studied in a trial) (source)
• Two hip-fracture trials did not establish better overall recovery. One stopped early over heart-failure concerns. (Studied in a trial) (source)
• Small studies found changes in deep and REM sleep. Long-term benefit for insomnia is unknown. (Studied in a trial) (source)
• Investigational for selected children with GH deficiency. A phase 3 trial is recruiting; there is no approved pediatric dose. (Studied in a trial) (source)
• A 563-person Alzheimer trial raised IGF-1 without slowing clinical decline. (Studied in a trial) (source)
• People report using it for bulking, hunger and sleep. Forum reports cannot separate drug effects from training, diet or other drugs. (Reported by users) (source)