hCG research: studies, doses and safety

A fertility hormone with limited testosterone add-on evidence and no proven weight-loss benefit.

Also called: human chorionic gonadotropin, human chorionic gonadotrophin, chorionic gonadotropin, choriogonadotropin alfa, Pregnyl, Novarel, Ovidrel, Ovitrelle.

Reproductive axis peptides · LH/chorionic gonadotropin receptor agonist; glycoprotein hormone · Evidence: Approved drug.

One review covers 44 studies in men with hormone deficiency; female fertility research is broader. Sperm evidence during testosterone therapy is limited, and newer large studies did not measure fertility.

Key studies

  • TRT: 125, 250 or 500 IU: Preserved testicular testosterone did not establish fertility protection. (source)
  • Very low-dose hCG: 15–125 IU: Very low doses raised testicular testosterone, without proving a fertility regimen. (source)
  • TRT: 26-man semen cohort: Preserved semen in a small cohort does not guarantee fertility during TRT. (source)
  • Sperm recovery after testosterone: Sperm often returned with combined care; the separate hCG effect is unknown. (source)
  • Older men: 5,000 IU twice weekly: Hormone and lean-mass changes did not improve strength or function. (source)
  • Male fertility: 44 gonadotropin studies: hCG plus FSH-based regimens can induce sperm in hormone deficiency. (source)

Related to hCG

Sources

Sources checked: 2026-10-18.

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