How to reconstitute hCG: mixing and storage
A fertility hormone with limited testosterone add-on evidence and no proven weight-loss benefit.
Also called: human chorionic gonadotropin, human chorionic gonadotrophin, chorionic gonadotropin, choriogonadotropin alfa, Pregnyl, Novarel, Ovidrel, Ovitrelle.
Reproductive axis peptides · LH/chorionic gonadotropin receptor agonist; glycoprotein hormone · Evidence: Approved drug.
Comes as: Urinary hCG lyophilized vial labelled in IU, Ovidrel 250 mcg/0.5 mL single-dose prefilled syringe.
Mixed with: Use supplied diluent. Pregnyl has 0.9% benzyl alcohol with saline; Novarel supplies bacteriostatic water..
- Pregnyl: 10,000 IU vial; label allows 1–10 mL supplied solvent. Gently dissolve; do not shake or freeze.
- Novarel: 5,000 or 10,000 USP-unit presentations; follow the exact product instructions.
- Ovidrel is ready to inject and single use; discard leftovers.
- The mg vial-size field is empty because IU cannot be converted to mass by one universal factor.
Before mixing: Pregnyl: 15–30°C. Novarel: room temperature. Ovidrel: 2–8°C; patient storage up to 30 days at ≤25°C is permitted.
After mixing: Pregnyl: 2–8°C, discard after 60 days. Novarel: 2–8°C, use within 30 days. These limits are product-specific.
Related to hCG
- Kisspeptin-10: A short-acting experimental peptide that triggers reproductive hormone release.
- Gonadorelin: A short-acting fertility hormone used in tests and specialist pump therapy.
Sources
- Compounding and the FDA: Questions and Answers, FDA · FDA · 2026
- The 2026 Prohibited List, World Anti-Doping Agency · WADA · 2026
- Therapeutic Goods (Poisons Standard—October 2026) Instrument 2026, Australian Government · Australian Government · 2026
- NOVAREL- gonadotrophin, chorionic kit, Ferring · 2025
- Ovitrelle, European Medicines Agency · 2025
- Ovitrelle, INN-choriogonadotropin alfa, European Medicines Agency · 2025
- Diagnosis and Treatment of Infertility in Men: AUA/ASRM Guideline (2020; Amended 2024), AUA/ASRM · 2024
- OVIDREL- choriogonadotropin alfa injection, solution, EMD Serono · 2023
- Notice to Compounders: Changes that affect compounding as of March 23, 2020, FDA · 2020
- Avoid Dangerous HCG Diet Products, FDA
- Ovitrelle 250 micrograms/0.5 mL solution for injection in pre-filled syringe, Merck
- PREGNYL- choriogonadotropin alfa kit, Organon
- Product information, Health Canada
- Pituitary Axis Impacts and Effectiveness of Clomiphene and Human Chorionic Gonadotropin in Treating Hypogonadism: Cohort Study., Clift AK et al. · The world journal of men's health · 2026
- Real-World Outcomes and Safety of Testosterone Therapy: A Longitudinal, Retrospective Cohort Study of Over 9,000 Men., Clift AK et al. · The world journal of men's health · 2026
Sources checked: 2026-10-18.
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