What does CJC-1295 with DAC do? Benefits and evidence
An experimental long-acting peptide that triggers growth hormone release, with no proven muscle or recovery benefit.
Also called: CJC-1295 DAC, DAC:GRF, DAC-GRF.
GHRH analogues · Long-acting GHRH receptor agonist with an albumin-binding tag.
CJC-1295 with DAC is an experimental injection that raises growth hormone and IGF-1 for days. Small human studies measured hormones, not muscle gain, recovery or longevity. An HIV trial stopped early and has no published results. Flushing, headaches and injection reactions were frequent. It has no FDA approval.
- In small studies, one shot raised growth hormone and IGF-1 for days; muscle gain and recovery were not tested. (Studied in a trial)
- With weekly or every-other-week shots, IGF-1 levels stayed raised in a small study. (Studied in a trial)
- People report using it for muscle, body shape, skin, sleep and injury recovery. (Reported by users)
- Individual users report better mood, energy, strength or endurance; this does not show the drug caused it. (Reported by users)
Uses in the sources
- Studied for GH and IGF-1 release in healthy adults; a terminated HIV visceral-fat study has no posted results. (Studied in a trial) (source)
- People report use for muscle and body composition. Controlled trials have not established these benefits. (Reported by users) (source)
- Reported for exercise and injury recovery; hormone increases do not establish faster healing. (Reported by users) (source)
- Sleep improvement is a reported reason for use, not an established treatment effect. (Reported by users) (source)
Related to CJC-1295 with DAC
- CJC-1295 without DAC: A peptide intended to trigger growth hormone release, with no human dosing study found.
- Tesamorelin: A peptide approved for deep abdominal fat in adults with HIV lipodystrophy.
- Sermorelin: An experimental short-acting peptide that triggers growth hormone release, with limited evidence of adult benefits.
- Ipamorelin: An experimental peptide that triggers growth hormone release.
Sources
- 21 CFR 216.23 — Bulk drug substances that can be used to compound drug products in accordance with section 503A of the Federal Food, Drug, and Cosmetic Act., Office of the Federal Register · eCFR · 2026
- 503B Bulk Drug Substances List, FDA · FDA · 2026
- Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks, FDA · FDA · 2026
- Concerns regarding the public health risks associated with unapproved peptide products, Therapeutic Goods Administration and Chief Medical Officer · Therapeutic Goods Administration · 2026
- Medicines, European Medicines Agency · European Medicines Agency · 2026
- The 2026 Prohibited List, World Anti-Doping Agency · WADA · 2026
- Therapeutic Goods (Poisons Standard—October 2026) Instrument 2026, Australian Government · Australian Government · 2026
- Think twice before injecting peptides bought online: unauthorized products can seriously harm you, Health Canada · Health Canada · 2026
- EGRIFTA WR (tesamorelin) for injection, for subcutaneous use, U.S. Food and Drug Administration · FDA · 2025
- Supply unlicensed medicinal products (specials), MHRA · 2025
- December 4, 2024 Pharmacy Compounding Advisory Committee Meeting, FDA · 2024
- FDA Briefing Document Pharmacy Compounding Advisory Committee (PCAC) Meeting December 4, 2024, US Food and Drug Administration · 2024
- Anticoagulant medicines - Side effects, NHS
- DailyMed - GLUCOTROL XL- glipizide tablet, extended release, Pfizer Inc. · DailyMed
- Know When to Go to the ER, American College of Emergency Physicians · American College of Emergency Physicians
Sources checked: 2026-10-18.
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