How to reconstitute CagriSema: mixing and storage

An unapproved cagrilintide–semaglutide combination with phase 3 weight-loss and diabetes results.

Also called: Cagrilintide/semaglutide, Cagrilintide-semaglutide, CagriSema 2.4 mg/2.4 mg.

Amylin analogues · Combination of an amylin analogue and a GLP-1 receptor agonist.

Comes as: Dual-chamber, single-use prefilled trial pen., Community-reported freeze-dried equal-dose blend vials..

Mixed with: Bacteriostatic water is reported online; no approved reconstitution diluent exists for home blends..

Common vial sizes: 10 mg. Common water amounts: 2 mL.

  • A reported 10 mg total vial contains 5 mg of each drug; retain both component amounts.
  • A 5 mg + 5 mg vial with 2 mL contains 2.5 mg/mL of each drug, or 5 mg/mL total.
  • Online advice about saline, water and acid conflicts. No validated home pH-adjustment procedure was found.
  • Trial pens keep the formulations controlled; home co-mixing is not equivalent.

Before mixing: Follow trial-specific instructions for study devices. No validated home-blend storage conditions were found.

After mixing: No validated stability period for home blends was found; a clear solution does not prove sterility.

Related to CagriSema

Sources

Sources checked: 2026-10-18.

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