How to reconstitute Cagrilintide: mixing and storage
An unapproved weekly amylin analogue with weight-loss trials and common stomach symptoms.
Also called: AM833, NNC0174-0833, NN9838, Cagri.
Amylin analogues · Long-acting amylin analogue; amylin and calcitonin receptor agonist.
Comes as: Trial injection solutions in controlled devices., Community-reported freeze-dried vials; no approved home-use product..
Mixed with: Community reports use bacteriostatic water; compatibility and shelf life are not established..
Common vial sizes: 5, 10 mg. Common water amounts: 1, 2 mL.
- Community examples: 5 mg with 1 mL, or 10 mg with 2 mL. These describe reports, not validated handling.
- Do not transfer storage instructions from an approved semaglutide pen to cagrilintide powder.
- No verified at-home acid-adjustment method or beyond-use date was located.
Before mixing: No validated storage temperature or shelf life for community powder vials was found.
After mixing: No validated home-mix stability or sterility period was found. Refrigeration does not prove either.
Related to Cagrilintide
- CagriSema: An unapproved cagrilintide–semaglutide combination with phase 3 weight-loss and diabetes results.
- Pramlintide: A diabetes medicine that copies a hormone released with insulin; Symlin products are discontinued.
- Semaglutide: A GLP-1 medicine with strong weight, glucose, heart and kidney evidence; dose and formulation matter.
- Tirzepatide: A weekly GIP/GLP-1 injection with strong diabetes and weight-loss evidence and common stomach side effects.
- Retatrutide: An experimental weekly injection with phase 3 weight-loss results.
Sources
- 503B Bulk Drug Substances List, FDA · FDA · 2026
- The Prohibited List, World Anti-Doping Agency · World Anti-Doping Agency · 2026
- Nutritional priorities to support GLP-1 therapy for obesity: a joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society., Mozaffarian D et al. · The American journal of clinical nutrition · 2025
- Bulk Drug Substances Used in Compounding Under Section 503A of the FD&C Act
- Chest pain, NHS
- European Medicines Agency decision P/0307/2023 of 4 August 2023 on the granting of a product specific waiver for cagrilintide / semaglutide (EMEA-003059-PIP02-23)
- FDA’s Concerns with Unapproved GLP-1 Drugs Used for Weight Loss, US Food and Drug Administration
- PIP Search Page, MHRA
- SYMLINPEN- pramlintide acetate injection
- Therapeutic Goods (Poisons Standard—October 2026) Instrument 2026
- Understanding your responsibilities when importing, compounding and supplying unapproved peptide products
- Vision loss, NHS
- Cagrilintide-semaglutide (CagriSema) versus semaglutide or cagrilintide in people with type 2 diabetes (REIMAGINE 2): a double-blind, randomised, controlled, phase 3 study., Buse JB et al. · The lancet. Diabetes & endocrinology · 2026
- Efficacy and Safety of Cagrilintide and Cagrisema Versus Semaglutide as Anti-Obesity Medications: A Systematic Review, Meta-Analysis and Meta-Regression., Ahmed M et al. · Diabetes, obesity & metabolism · 2026
- Renal or Hepatic Impairment Does Not Affect Pharmacokinetics, Safety, or Tolerability of Subcutaneous Cagrilintide., Nielsen MJF et al. · Clinical pharmacokinetics · 2026
Sources checked: 2026-10-18.
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