Bremelanotide dosage: reported doses and schedule
An as-needed injection for low libido before menopause; nausea is common.
Also called: PT-141, PT141, Vyleesi.
Melanocortin agonists · Melanocortin receptor agonist · Evidence: Approved drug.
Typical reported dose: 1.75 mg as needed, at most once in 24 hours
- Vyleesi: 1.75 mg as needed: Inject 1.75 mg subcutaneously via the autoinjector to the abdomen or thigh. as needed; no more than one dose within 24 hours, under the skin. Drug label. Studied in: Premenopausal women with acquired, generalized HSDD. (source)
- Dose finding: 0.75 mg: 0.75 mg as needed; no more than once daily or 16 doses per 4 weeks, under the skin. Studied in a trial. Studied in: Premenopausal women with desire and/or arousal problems. (source)
- Dose finding: 1.25 mg: 1.25 mg as needed; no more than once daily or 16 doses per 4 weeks, under the skin. Studied in a trial. Studied in: Premenopausal women with desire and/or arousal problems. (source)
- Dose finding: 1.75 mg: 1.75 mg as needed; no more than once daily or 16 doses per 4 weeks, under the skin. Studied in a trial. Studied in: Premenopausal women with desire and/or arousal problems. (source)
- RECONNECT: fixed 1.75 mg: 1.75 mg as needed; at least 24 hours apart, under the skin. Studied in a trial. Studied in: Premenopausal women with acquired, generalized HSDD. (source)
- Early injection: 4 mg: 4 mg single study-visit dose, under the skin. Studied in a trial. Studied in: Men with poor sildenafil response. (source)
Highest studied: Single monitored SC dose, not a repeated-dose safety limit..
These are doses reported in labels, trials or user reports, not a personal plan. Check the source behind each one.
Related to Bremelanotide
- Melanotan II: An unapproved tanning peptide with small human trials and reports of serious harm.
- Melanotan I / Afamelanotide: The molecule in an approved EPP implant; online tanning powder is a different formulation.
- Setmelanotide: A daily injection approved for specific genetic obesity and acquired hypothalamic obesity.
- Tirzepatide: A weekly GIP/GLP-1 injection with strong diabetes and weight-loss evidence and common stomach side effects.
Sources
- 503B Bulk Drug Substances List, FDA · FDA · 2026
- Bulk Drug Substances Used in Compounding Under Section 503A of the FD&C Act, FDA · FDA · 2026
- Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks, FDA · FDA · 2026
- Compounding and the FDA: Questions and Answers, FDA · FDA · 2026
- Scenesse, INN-afamelanotide, 2026
- The 2026 Prohibited List, World Anti-Doping Agency · WADA · 2026
- Therapeutic Goods (Poisons Standard—October 2026) Instrument 2026, Australian Government · Australian Government · 2026
- DailyMed - VYLEESI- bremelanotide injection, 2025
- Priapism (painful erections) - NHS, NHS · 2023
- NDA 210557 Multi-disciplinary Review and Evaluation: Vyleesi (bremelanotide), 2019
- Female Sexual Desire, Arousal, and Orgasmic Dysfunctions: A Systematic Review and Meta-Analysis of Treatment Options., Toledo RG et al. · Journal of minimally invasive gynecology · 2026
- Effect of bremelanotide on body weight of obese women: Data from two phase 1 randomized controlled trials., Spana C et al. · Diabetes, obesity & metabolism · 2022
- Re-Analyzing Phase III Bremelanotide Trials for "Hypoactive Sexual Desire Disorder" in Women., Spielmans GI et al. · Journal of sex research · 2021
- Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials., Kingsberg SA et al. · Obstetrics and gynecology · 2019
- Long-Term Safety and Efficacy of Bremelanotide for Hypoactive Sexual Desire Disorder., Simon JA et al. · Obstetrics and gynecology · 2019
Sources checked: 2026-10-18.
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