Bremelanotide dosage: reported doses and schedule

An as-needed injection for low libido before menopause; nausea is common.

Also called: PT-141, PT141, Vyleesi.

Melanocortin agonists · Melanocortin receptor agonist · Evidence: Approved drug.

Typical reported dose: 1.75 mg as needed, at most once in 24 hours

  • Vyleesi: 1.75 mg as needed: Inject 1.75 mg subcutaneously via the autoinjector to the abdomen or thigh. as needed; no more than one dose within 24 hours, under the skin. Drug label. Studied in: Premenopausal women with acquired, generalized HSDD. (source)
  • Dose finding: 0.75 mg: 0.75 mg as needed; no more than once daily or 16 doses per 4 weeks, under the skin. Studied in a trial. Studied in: Premenopausal women with desire and/or arousal problems. (source)
  • Dose finding: 1.25 mg: 1.25 mg as needed; no more than once daily or 16 doses per 4 weeks, under the skin. Studied in a trial. Studied in: Premenopausal women with desire and/or arousal problems. (source)
  • Dose finding: 1.75 mg: 1.75 mg as needed; no more than once daily or 16 doses per 4 weeks, under the skin. Studied in a trial. Studied in: Premenopausal women with desire and/or arousal problems. (source)
  • RECONNECT: fixed 1.75 mg: 1.75 mg as needed; at least 24 hours apart, under the skin. Studied in a trial. Studied in: Premenopausal women with acquired, generalized HSDD. (source)
  • Early injection: 4 mg: 4 mg single study-visit dose, under the skin. Studied in a trial. Studied in: Men with poor sildenafil response. (source)

Highest studied: Single monitored SC dose, not a repeated-dose safety limit..

These are doses reported in labels, trials or user reports, not a personal plan. Check the source behind each one.

Work out syringe units with the dosing calculator

Related to Bremelanotide

Sources

Sources checked: 2026-10-18.

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