How Adipotide works
A fat-blood-vessel targeting peptide with monkey weight-loss data and kidney toxicity.
Also called: FTPP, FTTP, Prohibitin-TP01, Prohibitin-targeting peptide 1, CKGGRAKDC-GG-D(KLAKLAK)2.
Fat-loss peptides · Prohibitin-targeted proapoptotic peptidomimetic.
One part binds prohibitin on blood vessels that feed white fat. Another part damages the cell’s energy machinery and triggers cell death. This reduced fat in animals. Reduced eating also contributed; the same effect has not been shown in people.
- Cell-surface prohibitin in white-fat blood vessels: The CKGGRAKDC targeting sequence helps deliver the attached cell-killing peptide.
- Mitochondrial membranes: The D(KLAKLAK)2 part disrupts cell energy machinery after entering a target cell.
- Food-intake regulation: Reduced eating explained much of the weight loss in rodent studies; the signal remains unclear.
Half-life: Human half-life is unknown; planned blood sampling produced no public results.
Related to Adipotide
- AOD-9604: A growth-hormone fragment whose largest obesity trial failed to show meaningful weight loss.
- Tirzepatide: A weekly GIP/GLP-1 injection with strong diabetes and weight-loss evidence and common stomach side effects.
- Retatrutide: An experimental weekly injection with phase 3 weight-loss results.
- Tesamorelin: A peptide approved for deep abdominal fat in adults with HIV lipodystrophy.
- SS-31 (elamipretide): A peptide approved for Barth syndrome muscle strength; benefit needs confirmation and broader energy benefits remain unproven.
Sources
- 21 CFR 216.23 — Bulk drug substances that can be used to compound drug products in accordance with section 503A of the Federal Food, Drug, and Cosmetic Act., Office of the Federal Register · eCFR · 2026
- 503B Bulk Drug Substances List, FDA · FDA · 2026
- Acute kidney injury (AKI), NHS · 2026
- Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the Federal Food, Drug, and Cosmetic Act, FDA · FDA · 2026
- Bulk Drug Substances Used in Compounding Under Section 503A of the FD&C Act, FDA · FDA · 2026
- Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks, FDA · FDA · 2026
- Concerns regarding the public health risks associated with unapproved peptide products, Therapeutic Goods Administration and Chief Medical Officer · Therapeutic Goods Administration · 2026
- MHRA Products | Home, MHRA · MHRA · 2026
- The 2026 Prohibited List, World Anti-Doping Agency · WADA · 2026
- Bulk Drug Substances Nominated for Use in Compounding Under Section 503B of the Federal Food, Drug, and Cosmetic Act, FDA · FDA · 2025
- Anaphylaxis, NHS · NHS · 2023
- Drugs@FDA: FDA-Approved Drugs, US Food and Drug Administration
- Search criteria - Drug Product Database online query, Health Canada · Health Canada
- Union Register, European Commission
- Safety and Risk Assessment of No-Prescription Online Semaglutide Purchases., Ashraf AR et al. · JAMA network open · 2024
Sources checked: 2026-10-18.
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