How Ac-SDKP works
An experimental repair peptide with old human studies, but no proven healing dose.
Also called: AcSDKP, Goralatide, Seraspenide, N-acetyl-seryl-aspartyl-lysyl-proline, Thymosin beta-4 fragment 1–4, TB4-Frag.
Healing and repair peptides · Endogenous tetrapeptide; thymosin beta-4 N-terminal fragment.
The body cuts Ac-SDKP from thymosin beta-4. In experiments it slows some blood-forming cells, lowers inflammation and scar signals, and can help new blood vessels grow. The ACE enzyme breaks it down quickly. These actions have not established a healing benefit in people.
- TGF-beta/Smad and inflammatory signals: Reduces scar-forming and inflammatory responses in experimental models.
- Blood-forming stem and progenitor cells: Can keep early blood-forming cells from entering the cell cycle.
- Blood-vessel growth: Promotes vessel formation in some animal and cell models.
- ACE N-terminal domain: Breaks down Ac-SDKP; ACE inhibitors raise natural blood levels.
Half-life: Mean 4.5 minutes after stopping IV infusion in six healthy volunteers.
Related to Ac-SDKP
- BPC-157: An experimental repair peptide with mostly animal evidence and a few small human reports.
- TB-500: A short piece of thymosin beta-4 with no proven repair benefit in humans.
- GHK-Cu: A copper-binding skin peptide with small topical studies and untested systemic injections.
- AHK-Cu: A copper peptide used in scalp serums, with laboratory findings and weak patent-only human data.
- Thymosin beta-4: A peptide studied for eye conditions and skin wounds; tendon-repair injections lack controlled human evidence.
- ARA-290: Experimental peptide studied for small-fiber nerve damage, with uncertain pain relief and safety.
Sources
- 503B Bulk Drug Substances List, FDA · FDA · 2026
- Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the Federal Food, Drug, and Cosmetic Act, FDA · FDA · 2026
- Bulk Drug Substances Used in Compounding Under Section 503A of the FD&C Act, FDA · FDA · 2026
- Concerns regarding the public health risks associated with unapproved peptide products, Therapeutic Goods Administration and Chief Medical Officer · Therapeutic Goods Administration · 2026
- July 23-24, 2026: Meeting of the Pharmacy Compounding Advisory Committee - 07/23/2026, FDA · FDA · 2026
- MHRA Products | Home, MHRA · MHRA · 2026
- TGA warning on the risks of importing unapproved peptide products, Therapeutic Goods Administration · 2026
- The 2026 Prohibited List, World Anti-Doping Agency · WADA · 2026
- Therapeutic Goods (Poisons Standard—October 2026) Instrument 2026, Australian Government · Australian Government · 2026
- Bulk Drug Substances Nominated for Use in Compounding Under Section 503B of the Federal Food, Drug, and Cosmetic Act, FDA · FDA · 2025
- Anaphylaxis: MedlinePlus Medical Encyclopedia, MedlinePlus · MedlinePlus
- Cellulitis: MedlinePlus Medical Encyclopedia, MedlinePlus
- GORALATIDE, NIH NCATS
- GORALATIDE, FDA
- Recognizing medical emergencies: MedlinePlus Medical Encyclopedia, MedlinePlus
Sources checked: 2026-10-18.
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