Survodutide research: studies, doses and safety
A weekly dual-hormone injection with phase 3 weight-loss data and frequent stomach side effects.
Also called: BI 456906, BI456906, Survo.
GLP-1 / glucagon dual agonists · GLP-1 and glucagon receptor dual agonist.
36 registered human protocols found, including planned and unreported studies. Secondary analyses and meta-analyses reuse participants; they are not counted again.
Key studies
- First doses (Jungnik 2023): Early human results supported further dose testing. (source)
- Early repeat doses (Jungnik 2023): Early schedules produced weight loss and tolerability problems. (source)
- Early Japanese trial: Weight fell, but many could not complete dose escalation. (source)
- Phase 2 diabetes: Weight or glucose improved; stomach symptoms limited tolerability. (source)
- Phase 2 obesity: Weight or glucose improved; stomach symptoms limited tolerability. (source)
- Phase 2 MASH: Weight or glucose improved; stomach symptoms limited tolerability. (source)
Related to Survodutide
- Mazdutide: A weekly dual-hormone injection approved in China, with phase 3 weight-loss results.
- Tirzepatide: A weekly GIP/GLP-1 injection with strong diabetes and weight-loss evidence and common stomach side effects.
- Retatrutide: An experimental weekly injection with phase 3 weight-loss results.
Sources
- 21 CFR 216.23 — Bulk drug substances that can be used to compound drug products in accordance with section 503A of the Federal Food, Drug, and Cosmetic Act., Office of the Federal Register · eCFR · 2026
- 503B Bulk Drug Substances List, FDA · FDA · 2026
- Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the Federal Food, Drug, and Cosmetic Act, FDA · FDA · 2026
- Bulk Drug Substances Used in Compounding Under Section 503A of the FD&C Act, FDA · FDA · 2026
- FDA’s Concerns with Unapproved GLP-1 Drugs Used for Weight Loss, FDA · FDA · 2026
- Find product information about medicines, Medicines and Healthcare products Regulatory Agency · MHRA · 2026
- Medicines, European Medicines Agency · European Medicines Agency · 2026
- The 2026 Prohibited List, World Anti-Doping Agency · WADA · 2026
- The Prohibited List, World Anti-Doping Agency · World Anti-Doping Agency · 2026
- Understanding your responsibilities when importing, compounding and supplying unapproved peptide products, Therapeutic Goods Administration · Therapeutic Goods Administration · 2026
- WEGOVY- semaglutide injection, solution WEGOVY- semaglutide tablet, DailyMed · DailyMed · 2026
- Bulk Drug Substances Nominated for Use in Compounding Under Section 503B of the Federal Food, Drug, and Cosmetic Act, FDA · FDA · 2025
- Nutritional priorities to support GLP-1 therapy for obesity: a joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society., Mozaffarian D et al. · The American journal of clinical nutrition · 2025
- Australian Register of Therapeutic Goods (ARTG), Therapeutic Goods Administration · TGA
- Drug Product Database: Access the database, Health Canada · Health Canada
Sources checked: 2026-10-18.
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