Retatrutide dosage: reported doses and schedule

An experimental weekly injection with phase 3 weight-loss results.

Also called: LY3437943, LY-3437943, Reta.

GLP-1 / GIP / glucagon agonists · GIP, GLP-1 and glucagon receptor triple agonist.

Typical reported dose: 2 mg once a week to start, up to 12 mg

  • Phase 1 single dose: 0.1 mg: 0.1 mg once, on study day 1 once only, under the skin. Studied in a trial. Studied in: Healthy adults in the first-in-human study. (source)
  • Phase 1 single dose: 0.3 mg: 0.3 mg once, on study day 1 once only, under the skin. Studied in a trial. Studied in: Healthy adults in the first-in-human study. (source)
  • Phase 1 single dose: 1 mg: 1 mg once, on study day 1 once only, under the skin. Studied in a trial. Studied in: Healthy adults in the first-in-human study. (source)
  • Phase 1 single dose: 3 mg: 3 mg once, on study day 1 once only, under the skin. Studied in a trial. Studied in: Healthy adults in the first-in-human study. (source)
  • Phase 1 single dose: 4.5 mg: 4.5 mg once, on study day 1 once only, under the skin. Studied in a trial. Studied in: Healthy adults in the first-in-human study. (source)
  • Phase 1 single dose: 6 mg: 6 mg once, on study day 1 once only, under the skin. Studied in a trial. Studied in: Healthy adults in the first-in-human study. (source)

Highest studied: Highest repeated dose studied: 12 mg under the skin once weekly..

These are doses reported in labels, trials or user reports, not a personal plan. Check the source behind each one.

Work out syringe units with the dosing calculator

Related to Retatrutide

Sources

Sources checked: 2026-10-22.

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