Mecasermin dosage: reported doses and schedule

Typical reported dose: 0.04 mg per kg twice a day to start, up to 0.12 mg per kg

• US label, 0.04 mg/kg start: 0.04 mg/kg per dose twice daily for at least 1 week, then If tolerated, 0.08 mg/kg per dose twice daily for at least 1 week, then If tolerated, up to 0.12 mg/kg per dose twice daily twice daily, under the skin. Drug label. Studied in: FDA-labelled pediatric growth-failure indications, age 2 and older. (source)
• US label, 0.08 mg/kg start: 0.08 mg/kg per dose twice daily for at least 1 week, then If tolerated, up to 0.12 mg/kg per dose twice daily twice daily, under the skin. Drug label. Studied in: FDA-labelled pediatric growth-failure indications, age 2 and older. (source)
• EU label, 0.04 mg/kg start: 0.04 mg/kg per dose twice daily for at least 1 week, then If no significant adverse reactions, 0.08 mg/kg twice daily, then If tolerated after at least another week, maximum 0.12 mg/kg twice daily twice daily, under the skin. Drug label. Studied in: Children/adolescents ages 2–18 with severe primary IGF-1 deficiency. (source)
• Clinician-published cautious start: 0.04 mg/kg per dose twice daily in younger or hypoglycemia-prone children, then Increase more slowly as tolerated toward 0.1–0.12 mg/kg per dose twice daily; no fixed weekly schedule twice daily, under the skin. Clinician-published. Studied in: Children with confirmed severe primary IGF-1 deficiency. (source)
• Growth study, 80 mcg/kg: 80 mcg/kg per dose, twice daily twice daily, under the skin. Studied in a trial. Studied in: Children with GH receptor deficiency. (source)
• Growth study, 120 mcg/kg: 120 mcg/kg per dose, twice daily twice daily, under the skin. Studied in a trial. Studied in: Children with GH receptor deficiency. (source)

These are doses reported in labels, trials or user reports, not a personal plan. Check the source behind each one.

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