What does Mazdutide do? Benefits and evidence
A weekly dual-hormone injection approved in China, with phase 3 weight-loss results.
Also called: IBI362, IBI-362, LY3305677, LY-3305677, Xinermei.
GLP-1 / glucagon dual agonists · GLP-1 and glucagon receptor dual agonist · Evidence: Approved drug.
Mazdutide activates GLP-1 and glucagon receptors. China approved it for adult weight management and type 2 diabetes in 2025. It has phase 3 results, but no FDA or EMA label. Stomach symptoms are common, and long-term outcomes remain uncertain.
- In phase 3 trials, adults lost weight; China approved it for adult weight management in June 2025, but the US has not. (Studied in a trial)
- In type 2 diabetes trials, blood sugar improved, and early conference results favored it over semaglutide 1 mg. (Studied in a trial)
- Some people report more energy or better appetite control when pairing it with tirzepatide. (Reported by users)
Uses in the sources
Related to Mazdutide
- Survodutide: A weekly dual-hormone injection with phase 3 weight-loss data and frequent stomach side effects.
- Tirzepatide: A weekly GIP/GLP-1 injection with strong diabetes and weight-loss evidence and common stomach side effects.
Sources
- 21 CFR 216.23 — Bulk drug substances that can be used to compound drug products in accordance with section 503A of the Federal Food, Drug, and Cosmetic Act., Office of the Federal Register · eCFR · 2026
- 503B Bulk Drug Substances List, FDA · FDA · 2026
- Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the Federal Food, Drug, and Cosmetic Act, FDA · FDA · 2026
- Bulk Drug Substances Used in Compounding Under Section 503A of the FD&C Act, FDA · FDA · 2026
- FDA’s Concerns with Unapproved GLP-1 Drugs Used for Weight Loss, FDA · FDA · 2026
- Find product information about medicines, Medicines and Healthcare products Regulatory Agency · MHRA · 2026
- Medicines, European Medicines Agency · European Medicines Agency · 2026
- The 2026 Prohibited List, World Anti-Doping Agency · WADA · 2026
- The Prohibited List, World Anti-Doping Agency · World Anti-Doping Agency · 2026
- Understanding your responsibilities when importing, compounding and supplying unapproved peptide products, Therapeutic Goods Administration · Therapeutic Goods Administration · 2026
- WEGOVY- semaglutide injection, solution WEGOVY- semaglutide tablet, DailyMed · DailyMed · 2026
- Bulk Drug Substances Nominated for Use in Compounding Under Section 503B of the Federal Food, Drug, and Cosmetic Act, FDA · FDA · 2025
- Nutritional priorities to support GLP-1 therapy for obesity: a joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society., Mozaffarian D et al. · The American journal of clinical nutrition · 2025
- Weight loss medicine Mazdutide approved for commercialization in China, Shanghai Municipal Government · Shanghai Municipal Government · 2025
- Australian Register of Therapeutic Goods (ARTG), Therapeutic Goods Administration · TGA
Sources checked: 2026-10-18.
Information only, not medical advice. Peptifacts does not sell anything and does not link to sellers.