How to store Exenatide

An older GLP-1 with twice-daily and weekly forms, now widely discontinued.

Also called: Byetta, Bydureon, Bydureon BCise, exendin-4, AC2993, ITCA 650.

GLP-1 / GIP / glucagon agonists · GLP-1 receptor agonist · Evidence: Approved drug.

Comes as: Immediate release: 250 mcg/mL ready-made pens delivering 5 or 10 mcg, Historical BCise: 2 mg/0.85 mL microsphere suspension in a single-use autoinjector.

Mixed with: None for immediate-release pens or BCise. BCise is premixed in an oil-based vehicle; do not add water..

  • For BCise, allow at least 15 minutes to reach room temperature, then shake vigorously for at least 15 seconds.
  • BCise must look uniformly cloudy, white to off-white, without residual clumps. Follow the device instructions.
  • No supported grey-vial sizes, water volumes or home-mixed shelf life were found.

Before mixing: Refrigerate at 2–8°C; do not freeze. Store BCise flat in its carton, protected from light.

After mixing: Immediate-release pen: after first use ≤25°C, discard at 30 days. BCise: ≤30°C for a total of 4 weeks; use immediately after preparing.

Related to Exenatide

Sources

Sources checked: 2026-10-18.

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