How Amycretin works
An experimental fullness-hormone drug studied as daily tablets and weekly injections.
Also called: Zenagamtide, NNC0487-0111, NN9487, NN 9487.
Amylin / GLP-1 co-agonists · Unimolecular GLP-1 and amylin receptor agonist; also activates calcitonin receptors.
It copies two hormone signals that help control hunger and blood sugar. GLP-1 helps release insulin when blood sugar rises. Amylin adds a fullness signal. Cell tests also show calcitonin receptor activity; its separate effects in people are unclear.
- GLP-1 receptor: Helps signal fullness and release insulin when blood sugar is high.
- Amylin receptors: Adds signals that reduce eating and help people feel full.
- Calcitonin receptor: Activated in cell tests; its contribution to human benefits and harms is not established.
Half-life: About 3.3–4.1 days after injections in the first trial; 88.1 hours in people with normal kidney function in the kidney study.
Sources
- 21 CFR 216.23 — Bulk drug substances that can be used to compound drug products in accordance with section 503A of the Federal Food, Drug, and Cosmetic Act., Office of the Federal Register · eCFR · 2026
- 503B Bulk Drug Substances List, FDA · FDA · 2026
- Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the Federal Food, Drug, and Cosmetic Act, FDA · FDA · 2026
- Bulk Drug Substances Used in Compounding Under Section 503A of the FD&C Act, FDA · FDA · 2026
- FDA’s Concerns with Unapproved GLP-1 Drugs Used for Weight Loss, FDA · FDA · 2026
- The 2026 Prohibited List, World Anti-Doping Agency · WADA · 2026
- Therapeutic Goods (Poisons Standard—October 2026) Instrument 2026, Australian Government · Australian Government · 2026
- Bulk Drug Substances Nominated for Use in Compounding Under Section 503B of the Federal Food, Drug, and Cosmetic Act, FDA · FDA · 2025
- Wegovy PI, Novo Nordisk
- Efficacy and Safety of Glucagon-like Peptide-1 Receptor Agonists and Co-agonists for Weight Loss Among Adults Without Diabetes : An Updated Systematic Review., Moiz A et al. · Annals of internal medicine · 2026
- Efficacy and safety of once-daily oral zenagamtide, a novel unimolecular GLP-1 and amylin receptor agonist, in adults with type 2 diabetes: a multicentre, randomised, parallel, double-blind, placebo-controlled, dose-finding, phase 2 trial., Mora P et al. · Lancet (London, England) · 2026
- Efficacy and safety of once-weekly subcutaneous zenagamtide, a novel unimolecular GLP-1 and amylin receptor agonist, in type 2 diabetes: a multicentre, randomised, parallel, double-blind, placebo-controlled, dose-finding, phase 2 trial., Mora P et al. · Lancet (London, England) · 2026
- Novel Amylin-Based Therapies for Weight Management in Adults With Overweight or Obesity Without Diabetes: A Network Meta-Analysis., Kamrul-Hasan ABM et al. · Endocrinology, diabetes & metabolism · 2026
- Renal Impairment Does Not Affect Pharmacokinetics, Safety or Tolerability of Zenagamtide., Oldenburg LIK et al. · Diabetes, obesity & metabolism · 2026
- Supplementary appendix, Mora P et al. · The Lancet · 2026
Sources checked: 2026-10-18.
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